Hypoxic regulation of insulin receptor substrate 2 gene expression is differently regulated by endoplasmic reticulum stress and hydrocortisone in normal human astrocytes and glioblastoma cells
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Objective. The insulin receptor substrate 2 (IRS2) is phosphorylated by the tyrosine kinase activity of the insulin receptor and the insulin-like growth factor I (IGF-1) receptor upon receptor stimulation. It mediates insulin signaling controlling metabolism a... ...