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Novel eRF3a degrader enhances gentamicin-induced premature termination codon readthrough in epidermolysis bullosa

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Recessive dystrophic epidermolysis bullosa (RDEB) and junctional epidermolysis bullosa (JEB) are severe blistering skin disorders caused by mutations in genes encoding type VII collagen (COL7A1) and laminin 332 (LAMA3, LAMB3, or LAMC2), respectively. In RDEB, ... ...