Refining the AOP for retinoid-induced teratogenicity: Insights into RAR/RXR overactivation and RXR cross-talk with retinoic acid and thyroid hormone signaling
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Retinoic acid (RA), a vitamin A metabolite, plays a crucial and evolutionarily conserved role in vertebrate development. Chemical disruption of retinoid signaling can severely affect organisms; yet, despite its teratogenicity and pathway interactions, this dis... ...
