Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
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Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with an abasic (AP) site base excision repair intermediate. For 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining... ...
