DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
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Dicer has RNase activity and is an essential enzyme in microRNA (miRNA) biogenesis. Mutations in the DICER1 gene have been linked to various cancers, notably DICER1 syndrome. To investigate the impact of pathogenic hotspot mutations in DICER1-associated tumors... ...
