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Toonasonoids A-K, limonoids from Toona ciliata M. Roem, attenuate inflammatory response through mediating the PI3K/AKT/NF-κB pathway

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Eleven previously undescribed limonoids, toonasonoids A-K (1-11), and a known semi-synthetic analogue (12) with three basic carbon skeletons, were isolated from the twigs of Toona ciliata M. Roem. Among them, compounds 1-3 possessed a six-membered α,β-unsatu... ...