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The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice

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Proteasomes undergo dynamic changes in their types and activities during mammalian spermatogenesis. While the spermatogenesis-specific 20S proteasome (s20S), characterized by PSMA8 substitution of PSMA7, is known to be essential for meiosis I completion, the f... ...