Attenuated neurovirulence of dUTPase-deficient herpes simplex virus type 1 in suckling mice but not in newborn mice
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The HSV-1 UL50 gene encodes dUTPase (DUT), which dephosphorylates dUTP into dUMP, and its mutant strain is known to reduce neurovirulence in mice over 3 weeks old. Therefore, the UL50-deficient strain may be a candidate as a vaccine strain or viral vector. In ... ...
