GPC2-CAR T cells have potent preclinical activity against orthotopic medulloblastoma xenografts
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Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients with group 3 and 4 MB have poor clinical outcomes, underscoring the urgent need for new therapies. Glypican-2 (GPC2) is a recently discovered oncofetal antigen. Given its expre... ...