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Kaurenoic Acid Suppresses Osteosarcoma Progression by Reprogramming Tumor-Associated Macrophages to M1 Phenotype

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Osteosarcoma (OS) is the most prevalent primary malignant bone tumor. M2 type tumor-associated macrophages (TAMs) are the predominant infiltrating cells within the OS microenvironment and play a key role in promoting OS progression. Although kaurenoic acid (KA... ...