The Electric Genome: A Mechanistic Hypothesis for Nuclear Architecture and Gene Expression Bias: Chromatin Charge, Modulated by Genetic and Epigenetic Features, Establishes a Reproducible Radial Nuclear Architecture that Directs Transcription
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Genome organization is reproducible and linked to gene expression, but the forces shaping it remain poorly understood. This hypothesis proposes that chromatin positioning is directed by a weak radial electric field generated by the nuclear membrane potential. ... ...
