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Structure-Activity Relationships of Highly Potent and Selective A2B Adenosine Receptor Agonists

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A series comprised of N6-substituted adenosines designed from the A2B adenosine agonist 4 were synthesized and their A2BR potency was assessed in a cAMP accumulation assay using FlpINCHO cells stably expressing the human A2BR. This study identified 12 novel A2... ...