Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsules achieves effective combinatorial treatment of glioblastoma
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Glioblastoma (GB) is a highly malignant and the most lethal intracranial tumor. p53 mutations in GB patients, occurring in 30-50 % of cases, disrupt tumor-suppressive pathways and promote malignant progression. Advances in mRNA technology enable p53 restoratio... ...
