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Kinetic Mechanism of Heparin-Induced Fibrillation of α-Synuclein

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Deposition of fibrillar aggregates of α-synuclein (αS) in the brain is a hallmark of αS-associated neurodegenerative diseases. Heparin, a structural analog of cell-surface heparan sulfate, modulates the kinetics of αS fibrillation and the morphology of the... ...