Enzymatic synthesis of stable isotope-labeled SAM for screening hMAT2A inhibitors by using matrix-assisted laser desorption/ionization mass spectrometry
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A high-throughput method was developed for screening human MAT2A (hMAT2A) inhibitors by using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS). The stable isotope deuterium-labeled S-adenosylmethionine (SAM-D3) was enzymatically syn... ...
