Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth
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RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-κB activation through the assembly of intracellular membrane signalosomes in stimulated normal B cells and plays a B cell-intrinsic role in... ...
