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Solvent-Assisted Catalysis: Water Promotes Ring Closure Formation of 2‑Oxazolidinone from Amino Acid Derived N‑Boc-Epoxide

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Oxazolidinones are important heterocyclic compounds with several therapeutic properties, especially antimicrobial activity, as seen in linezolid. Unexpectedly, a 2-oxazolidinone structurally similar to linezolid was obtained, prompting optimization of the reac... ...