Palladium-catalyzed Heck/polyfluoroarylation of alkene-tethered carbamoyl chlorides with polyfluoroarenes
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We developed a Pd-catalyzed Heck/polyfluoroarylation cascade to synthesize polyfluoroarylated oxindoles with all-carbon quaternary centers from alkene-tethered carbamoyl chlorides. The reaction was extended to a three-component one-pot protocol using amines, B... ...