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The Immunoglobulin Domain of SISS-1/EGF is Required for its Function

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Epidermal growth factor (EGF) signaling plays roles in development and physiology across the animal kingdom. In the nematode C. elegans , a single EGF receptor (EGFR) and two EGF family ligands have been characterized. LIN-3 /EGF is required for a variety of d... ...