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High-order single-nucleotide polymorphism interactions between selected anti-oxidant and protease genes influence North Indians' propensity for chronic obstructive pulmonary disease (COPD) and lung function parameters

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Background: COPD causes persistent airflow restriction, oxidative stress, and inflammation. Proteins like MMP9, MMP12, and ADAM33, and antioxidant enzymes such as Glutathione Peroxidase, Superoxide Dismutase, and Catalase are cru... ...