A Pitstop-2 analog impairs viability of aggressive lung cancer cells by disrupting nuclear pore integrity
{{output}}
We previously demonstrated that Pitstop-2, an inhibitor of clathrin-mediated endocytosis (CME), exhibits CME-independent inhibitory effects on nuclear pore complexes (NPCs). Pitstop-2 interferes with β-propeller folds in both clathrin coats and NPC scaffold p... ...
