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Estradiol enhances thermoregulation induced by ostruthin, a TREK channel agonist, in ovariectomized rats

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Menopausal women frequently report contradictory thermoregulatory symptoms (hot flashes and chills), believed to result from declining estradiol (E₂) levels; however, mechanisms remain unclear. TWIK-related (TREK) potassium channels function as cold receptors... ...