Recombinant Trichosanthin-Loaded Nanoparticles with Tumor-Targeting and Cell-Penetrating Capabilities for Activatable Antitumor Therapy
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Trichosanthin (TCS), a type I ribosome-inactivating protein, exerts its cytotoxic effects by inhibiting protein synthesis through depurination of 28S rRNA, resulting in apoptosis and cancer cell death. However, insufficient tumor specificity and limited cell-p... ...
