Bicyclic Isosteres of Pyridine/Piperidine: From Synthesis to Applications
{{output}}
2-Azabicyclo[2.2.2]octanes have been designed, synthesized, and validated biologically as isosteres of piperidine/pyridine. The key reaction step was the cyclization of cyclic alkenyl amines with the KOtBu/I2/CO2 combination. The method proved to be scalable (... ...
