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OSBPL2 deficiency impaired cochlear blood-labyrinth barrier via activation of NF-κB signaling pathway

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OSBPL2 was one of the causal genes responsible for autosomal dominant non-syndromic hearing loss (DFNA) and the pathogenic mechanism of OSBPL2 mutations remain elusive. OSBPL2 was detected to be highly expressed in stria vascularis (SV) of mouse cochleae, in w... ...