Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
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Disruptive variants in the chromodomain helicase CHD8 are associated with risk for autism spectrum disorder (ASD). CHD8 haploinsufficiency is hypothesized to contribute to ASD by perturbing neurodevelopmental gene expression. However, insight into cell-type-sp... ...
