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Mechanism of oxidative stress and neurotoxicity associated with heme and copper-Aβ relevant to Alzheimer's disease

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Alzheimer's disease (AD) is a neurodegenerative disorder with a complex pathophysiology involving oxidative stress, amyloid β (Aβ) aggregation and dysregulation of metal ions, particularly copper and heme. The overproduction of reactive oxygen species (ROS)... ...