HPV-associated Endocervical Adenocarcinoma In Situ (AIS) With an ER+/Vimentin+/CEA- immunophenotype Mimicking Tubo-endometrioid Metaplasia
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HPV-associated endocervical adenocarcinoma in situ (AIS) is typically ER-, vimentin-, and CEA+. By contrast, tubo-endometrioid metaplasia (TEM), a well-known mimicker of AIS, is typically ER+, vimentin+, and CEA-. Both AIS and TEM express p16, with block-posit... ...
