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Rapaprotin, an Endopeptidase-Activated Proteasome Inhibitor that Induces 26S Disassembly

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The 19S regulatory particle (RP) associates with the 20S core particle (CP) to form the 26S proteasome, an evolutionarily conserved holoenzyme that plays key roles in both physiological and pathological processes. Proteasome inhibitors that target the catalyti... ...