Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity
{{output}}
Stabilization of amyloidogenic immunoglobulin light chains (LCs) by binding of small molecule "kinetic stabilizers" is under development as a novel treatment for light chain amyloidosis. From a high-throughput screen, we previously identified 16 full-length ... ...
