Improved Mass Analysis of Proteins and Protein Complexes Present in Common Biological Buffers and Physiological Concentrations of NaCl Using Solution Additives Delivered by Theta Emitters
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Native electrospray ionization-mass spectrometry (ESI-MS) is inherently susceptible to nonvolatile salts in solution, due to ion formation resulting from the so-called "charged-residue mechanism" (CRM). The presence of nonvolatile salts leads to peak broaden... ...