Distinct roles of tandem acyl carrier protein domains in the assembly of a macrocyclic polylactone
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Mutagenesis of the tandem acyl carrier protein (ACP1-ACP2) domains in the non-reducing polyketide synthase Men2 revealed their distinct roles in menisporopsin A biosynthesis. ACP1 is essential for multiple esterifications and cyclolactonisation, whilst ACP2 as... ...
