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Kisspeptin-dependent puberty onset triggered by increased Kiss1 and Pdyn expression in arcuate Tac3 neurons under reduced estrogen negative feedback and sufficient energy balance in female rats

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Introduction: The pre-pubertal quiescence of pulsatile gonadotropin-releasing hormone secretion in mammals is considered due to repressed Kiss1 (encoding kisspeptin) expression in kisspeptin/neurokinin B/dynorphin A (KNDy) neuron... ...