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A Structure-Guided Bifunctional Aptamer Mitigates Pseudomonas aeruginosa Virulence and Biofilms by Disrupting las and rhl Quorum Sensing Systems

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Quorum sensing (QS) is a microbial communication system that mediates the virulence factor synthesis and biofilm formation through signaling molecules. QS-targeted antivirulence strategies have emerged as a new approach to avoiding antibiotic resistance by wea... ...