Leukocyte Esterase-Activated Nanoconjugates Enables Precise Local Therapy of Ulcerative Colitis via Inflamed Tissue-Selective Drug Delivery
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Leukocyte esterase (LE), markedly upregulated in inflamed colonic tissues, offers a unique enzymatic trigger for selective drug activation in ulcerative colitis (UC). To exploit this pathological hallmark, we developed LE-activated nanoconjugates that enable i... ...
