Harnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of Brugia malayi: a hierarchical virtual screening and molecular dynamics simulation study
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Brugia malayi, a causative agent of lymphatic filariasis, relies on its endosymbiont Wolbachia for survival. MurE ligase, a key enzyme in Wolbachia peptidoglycan biosynthesis, serves as a promising drug target for anti-filarial therapy. In this study, we emplo... ...
