Role of the extracellular matrix in amylin aggregation: Opportunities for improved therapy in type 2 diabetes mellitus
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In most individuals with type 2 diabetes mellitus (T2DM), aggregation of amylin or islet amyloid polypeptide (IAPP) leads to β-cell apoptosis, impairs glucose-stimulated insulin secretion, and causes islet disorganisation (Cooper et al. 1987; Westermark and W... ...
