Synthesis of polymer-clindamycin conjugates through lipase-catalyzed esterification and RAFT polymerization
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Relative to free antibiotics, polymer-antibiotic conjugates (PACs) can possess modified solubility, sustained release behavior, and prolonged bioactivity in biological systems. As one of the most potent and ubiquitous antibiotics, clindamycin (Clin) has broad-... ...