Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology
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Serum and glucocorticoid-regulated kinase 1 (SGK1) is an underexplored kinase involved in several neurodegenerative diseases. Although SGK1 inhibitors are not available on the market, the absence of side effects in two SGK1 knockout mouse models supports the d... ...
