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Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection

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Monkeypox virus (MPXV) is a poxvirus endemic to Central and West Africa with high epidemic potential. Poxviruses enter host cells via a conserved entry-fusion complex (EFC), which mediates viral fusion to the cell membrane. The EFC is a promising therapeutic t... ...