Bioengineered human pre-vascularized microtissues reconstruct vascular niche and regenerative microenvironment to enhance functional skeletal muscle regeneration
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Skeletal muscle regeneration mediated by muscle satellite cells (MuSCs) is supported by the specific vascular niche containing endothelial cells, pericytes, and mesenchymal stem cells. Volumetric muscle loss (VML) severely disrupts the vascular niche and impai... ...
