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High-Specificity Detection of Ultraviolet Mutational Signatures in Circulating Tumor DNA for Diagnostic Classification of Cutaneous and Unknown Primary Tumors using FoundationOne Liquid CDx

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This study evaluated an ultraviolet (UV) mutational signature classifier applied to circulating tumor DNA (ctDNA) in cell-free DNA (cfDNA) liquid biopsies, using the FoundationOne Liquid CDx (F1LCDx) platform. Among 73,790 samples, 12.9% (9,527) met the varian... ...