Inactivation of BACE2 stimulates release of endothelin-1 from human brain microvascular endothelial cells
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Beta-site amyloid precursor protein cleaving enzyme 2 (BACE2) is one of the most downregulated genes in the brain capillary endothelial cells derived from patients with Alzheimer's disease (AD). Endothelin-1 (ET-1) significantly contributes to the pathogenesi... ...
