Subchronic oral administration of Tamoxifen in hormonally intact female rats induces dose-dependent maladaptive behavioral phenotypes
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Tamoxifen (TAM), the gold standard treatment for hormone-responsive breast cancer, is the most widely used Selective Estrogen Receptor Modulator (SERM). Based on the premise that subchronic oral administration of TAM may induce neurotoxic effects, we hypothesi... ...