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Design, Development and Optimization of Carmustine-Loaded Freeze-Dried Nanoliposomal Formulation Using 32 Factorial Design Approach

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The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation of anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome the dose-dependent side effects and improve... ...