High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of PLK1 and NRP1
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Overexpression of PLK1 and NRP1 correlate with enhanced proliferative activity in lung cancer cells, thus the development of dual-target PLK1/NRP1 inhibitors holds great therapeutic promise. In this study, five compounds (PLN 1-5) targeting both PLK1 and NRP1 ... ...
