Endogenous Pigment Mimicking Engineered Nanovesicle Targets Extrasynaptic NMDA Receptors against Ca2+-Mediated Excitotoxicity in Alzheimer's Disease
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In Alzheimer's disease (AD), deposition of toxic Aβ42 oligomers causes excessive internalization of 2A subunit dominant NMDA receptors (GluN2A subtype) from the synaptic region. This causes a significant reduction of the synaptic glutamate interaction site. ... ...
