ATF4 transcriptionally activates NUPR1 to promote ferroptosis in chondrocytes and osteoarthritis development
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Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage destruction and inflammation. This study reveals that activating transcription factor 4 (ATF4) is upregulated in IL-1β-treated chondrocytes and promotes ferroptosis, a form ... ...
