Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality
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Background: Homoharringtonine (HHT), a natural product used clinically to treat acute myeloid leukemia (AML) in combination with chemotherapy, induced transient remission in 25 % of unclassified AML patients when administered alo... ...
