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HLF transactivates TFEB to promote gallbladder cancer stem cells' self-renewal and determines tumor response to distinct therapies

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Gallbladder cancer (GBC) is the most common malignancy in the biliary system and lacks biomarkers for personalized therapy. Here, we reported that hepatic leukemia factor (HLF) was highly expressed in gallbladder cancer stem cells (CSCs) and patients with gemc... ...